Midstream Health Partners With CommonSpirit Health to Deploy AI Financial Operations Platform

Under the partnership, Midstream’s platform will initially integrate with CommonSpirit’s supply chain operations to identify unrealized savings and revenue opportunities in real time.

Midstream Health has entered into a strategic partnership with CommonSpirit Health to deploy its AI-powered proactive financial action platform across the health system’s enterprise operations, the company announced Tuesday.

CommonSpirit Health, one of the largest nonprofit health systems in the United States, is also an investor in Midstream through CommonSpirit Ventures. The company is additionally backed by Andreessen Horowitz (a16z).

Under the partnership, Midstream’s platform will initially integrate with CommonSpirit’s supply chain operations to identify unrealized savings and revenue opportunities in real time. The platform uses AI agents to analyze contract and financial data across back-office functions, targeting areas such as missed rebates, pricing discrepancies, payer underpayments, and policy-driven denials.

According to the company, the system creates a consolidated financial data layer by aggregating fragmented contract and operational datasets. AI agents then flag and prioritize cost-saving or margin improvement opportunities and enable execution through automated workflows and analytics tools.

“Upon implementation, Midstream's AI agents provided measurable gains within days, surfacing opportunities like missed rebates and underpayments,” said Daniel Barchi, Chief Information Officer at CommonSpirit Health. “It is a closed-loop AI system that transforms financial intelligence into real-time action.”

Health systems are facing continued financial pressure from rising operating costs and reimbursement challenges. Midstream positions its platform as an always-on intelligence layer that continuously analyzes spend and revenue data, rather than operating as a one-time consulting engagement or point solution.

Jay Rughani, Partner at Andreessen Horowitz, said the platform is designed to operate within the complexity of healthcare financial systems. “It’s a purpose-built platform that thrives in the complexity of healthcare operations, compressing months of financial analysis into minutes,” he said.

Midstream stated that its AI platform allows teams to query financial data through chat-based interfaces, model potential outcomes, and trace findings back to source documentation. The company claims the system can generate measurable financial gains within days of deployment.

Sumit Kadakia, CEO and co-founder of Midstream, said the platform is designed to help health systems move from reactive financial management to proactive execution across spend and revenue operations.

Financial terms of the partnership were not disclosed.

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