Mount Sinai Launches AI Genomics Collaboration with NVIDIA

The partners will build a shared AI genomics platform that uses large language models and high-performance computing to analyze the noncoding 98 percent of the genome and uncover disease-linked regulatory mechanisms.

ARC Innovation at Sheba Medical Center in Israel and the Icahn School of Medicine at Mount Sinai in New York have announced a three-year collaboration with NVIDIA that aims to apply advanced AI to the least understood parts of the human genome.

The partners said the initiative is designed to “crack the hidden code” of the noncoding genome and unlock new routes for precision medicine.

The collaboration will focus on the 98 percent of the genome that does not directly code for proteins yet is believed to play a critical role in regulating gene expression and disease susceptibility.

Joint research teams will build an AI platform that uses large language models and high-performance computing to map the interplay of thousands of genomic regions, structural variants, and regulatory elements, with the goal of identifying underlying mechanisms that contribute to complex diseases and pointing to potential therapeutic targets.

At Sheba, the work will be co-led by the newly established AI Center at ARC, which acts as a hub for global partnerships at the intersection of medicine and AI.

At Mount Sinai, the initiative will be anchored within the Mount Sinai Million Health Discoveries Program, the flagship effort of the Charles Bronfman Institute for Personalized Medicine, the Winterich Department of Artificial Intelligence and Human Health, and the Hasso Plattner Institute for Digital Health.

Eric J. Nestler, dean of the Icahn School of Medicine at Mount Sinai, said the partnership demonstrates the power of global collaboration at the intersection of science, medicine and technology. “This initiative gives us a unique opportunity to decode uncharted regions of the genome and translate these discoveries into meaningful benefits for patients worldwide,” he said.

Joint teams from Sheba, Mount Sinai, and NVIDIA have already begun laying the foundations for the shared platform, intended for use by scientists and clinicians globally.

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