HHS Launches ‘OneHHS’ AI Strategy to Integrate AI Across Federal Health Agencies

The initiative marks a significant shift toward department-wide modernization, fulfilling the Trump Administration’s direction to expand the use of advanced technologies across federal operations.

The U.S. Department of Health and Human Services (HHS) has introduced a unified AI Strategy designed to embed artificial intelligence across its major divisions, including the CDC, CMS, and FDA. The initiative marks a significant shift toward department-wide modernization, fulfilling the Trump Administration’s direction to expand the use of advanced technologies across federal operations.

The strategy places the core objective—strengthening internal efficiency, supporting scientific rigor, and improving public health workflows—at the center of a consolidated model termed “OneHHS.” This approach brings every HHS agency under a common AI framework to streamline processes and reduce fragmentation across the federal health system.

Deputy Secretary Jim O’Neill said AI represents a disruptive step for healthcare delivery and federal operations, noting HHS’s intent to accelerate adoption across mission-critical functions.

Unified Framework for CDC, CMS, FDA, and NIH

For the first time, the Department is aligning its leading agencies under a single AI infrastructure. The framework extends to the Centers for Disease Control and Prevention (CDC), Centers for Medicare & Medicaid Services (CMS), Food and Drug Administration (FDA), and the National Institutes of Health (NIH). By consolidating infrastructure and data workflows, HHS aims to reduce operational silos and strengthen cybersecurity across high-risk health systems.

Five Pillars to Guide AI Deployment

The strategy, led by Acting Chief Artificial Intelligence Officer Clark Minor, aligns with previous OMB mandates and the Administration’s AI Action Plan. It is anchored in five core pillars:

• Governance and risk management to reinforce public trust.

• Infrastructure and platform design built around user needs.

• Workforce development and burden reduction to support efficiency.

• Health research reproducibility through validated scientific methods.

• Modernized care and public health delivery for improved outcomes.

Minor said the framework is structured to support workforce empowerment and guide strategic AI development across the Department’s programs and scientific initiatives.

Future Collaboration With Industry

While the first phase focuses solely on federal use, HHS indicates that the strategy will shape future partnerships with private-sector technology developers. The department expects coordinated engagement with industry players as it builds standards for secure, scalable AI solutions in public health and healthcare administration.

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